Melanoma Cells Present a MAGE - 3 Epitope to CD 4 1 Cytotoxic T Cells in Association with Histocompatibility Leukocyte Antigen DR 11
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چکیده
From the * Laboratory of Tumor Immunology, the ‡ Cancer Immunotherapy and Gene Therapy Program, and the § Laboratory of Molecular Tissue Typing and i Immunochemistry Unit, Department of Biology and Technology (DIBIT), Scientific Institute H. San Raffaele, 20132 Milan, Italy; ¶ Roche Milano Ricerche, 20132 Milan, Italy; ** Roche Discovery Technologies, Hoffman-La Roche, Inc., Nutley, New Jersey 07110; and ‡‡ Departement Chirurgie, Kantonsspital, CH-4031 Basel, Switzerland
منابع مشابه
Melanoma Cells Present a MAGE-3 Epitope to CD4+ Cytotoxic T Cells in Association with Histocompatibility Leukocyte Antigen DR11
In this study we used TEPITOPE, a new epitope prediction software, to identify sequence segments on the MAGE-3 protein with promiscuous binding to histocompatibility leukocyte antigen (HLA)-DR molecules. Synthetic peptides corresponding to the identified sequences were synthesized and used to propagate CD4(+) T cells from the blood of a healthy donor. CD4(+) T cells strongly recognized MAGE-328...
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MAGE-type genes are expressed by many tumors of different histological types and not by normal cells, except for male germline cells, which do not express major histocompatibility complex (MHC) molecules. Therefore, the antigens encoded by MAGE-type genes are strictly tumor specific and common to many tumors. We describe here the identification of the first MAGE-encoded epitopes presented by hi...
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تاریخ انتشار 1999